Kern, Fritz, Privatdozent. Acta imperii, Angliae et Franciae ab a. 1267 ad a. 1313

Acta Mathematica et Informatica Universitatis Ostraviensis

1. I n t r o d u c t i o n In 1640, Pierre de Fermat conjectured that all numbers F m = 2 2 ' " + 1 for m = 0, 1, 2 , . . . , (1) are prime, which was later found to be incorrect. The numbers Fm are called Fermat numbers after him. If Fm is prime, we say that it is a Fermat prime. Until the end of the 18th century, Fermat numbers were most likely a mathe­ matical curiosity. The interest in the ...

Dmd064527 1267..1276

Delamanid, a new anti-tuberculosis drug, is metabolized to M1, a unique metabolite formed by cleavage of the 6-nitro-2,3dihydroimidazo[2,1-b] oxazole moiety, in plasma albumin in vitro. The metabolic activities in dogs and humans are higher than those in rodents. In this study, we characterized the pharmacokinetics and metabolism of delamanid in animals and humans. Eight metabolites (M1–M8) pro...

29.9 Kern

The fabrication methods of the microelectronics industry have been refined to produce ever smaller devices, but will soon reach their fundamental limits. A promising alternative route to even smaller functional systems with nanometre dimensions is the autonomous ordering and assembly of atoms and molecules on atomically well-defined surfaces. This approach combines ease of fabrication with exqu...

Npgrj_nbt_1352 1307..1313

We identify a cytochrome P450 gene (CYP6AE14) from cotton bollworm (Helicoverpa armigera), which permits this herbivore to tolerate otherwise inhibitory concentrations of the cotton metabolite, gossypol. CYP6AE14 is highly expressed in the midgut and its expression correlates with larval growth when gossypol is included in the diet. When larvae are fed plant material expressing double-stranded ...

A note on Fritz John sufficiency